2017/02/02 by Marcus M. Monroe, Luke Buchmann, Jason P. Hunt +3 · 1 citation
Medicine · #Head and Neck Cancer Studies #Esophageal Cancer Research and Treatment #Head and Neck Surgical Oncology
paper · pdf · doi:10.1002/lio2.64
openalex publication_date 2017/02/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
IMPORTANCE: The benefit of adjuvant radiation in surgically treated T1-2N1 oropharyngeal cancer without adverse pathologic features remains unclear. OBJECTIVES: To compare population-level survival outcomes in surgically-treated T1-2N1 oropharyngeal squamous cell carcinoma (OPSCC) with and without the use of adjuvant radiation. STUDY DESIGN: Retrospective population-based study using the Surveillance, Epidemiology, and End Results (SEER) registry data from 1998-2011. SETTING: Population-level study. PARTICIPANTS: Patients with T1-2N1 OPSCC treated with surgical resection and neck dissection with or without adjuvant radiation. INTERVENTIONS FOR CLINICAL TRIALS OR EXPOSURES FOR OBSERVATIONAL STUDIES: The use of postoperative adjuvant radiation. MAIN OUTCOMES AND MEASURES: Overall and disease-specific survival. RESULTS: Radiation was utilized in 74% of patients and was positively associated with extracapsular extension and well-differentiated histology. The use of radiation was associated with improved mean overall survival (124 v. 108 months, p=0.023) and a non-significant increase in mean disease-specific survival (138 v. 131 months, p=0.053). CONCLUSIONS AND RELEVANCE: The use of adjuvant radiation is associated with improved survival in surgically-treated T1-2N1 squamous cell carcinoma of the oropharynx with unknown HPV status. LEVEL OF EVIDENCE: IV.