Neuronal degeneration and mitochondrial dysfunction

2003/02/01 by Eric A. Schon, Giovanni Manfredi · 27 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Mitochondrial Function and Pathology #Metabolism and Genetic Disorders #Neurological diseases and metabolism

paper · doi:10.1172/jci200317741

Abstract

Parkinson disease (PD); familial Parkinson disease (FPD); Alzheimer disease (AD); familial Alzheimer disease (FAD); amyotrophic lateral sclerosis (ALS); sporadic amyotrophic lateral sclerosis (SALS); oxidative phosphorylation (OXPHOS); reactive oxygen species (ROS); mitochondrial DNA (mtDNA); ribosomal RNA (rRNA); transfer RNA (tRNA); nuclear DNA (nDNA); inner mitochondrial membrane (IMM); intermembrane space (IMS); mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS); myoclonus epilepsy with ragged-red fibers (MERRF); ragged-red fiber (RRF); Kearns-Sayre syndrome (KSS); progressive external ophthalmoplegia (PEO); cytochrome c oxidase (CCO); Leber hereditary optic neuropathy (LHON); Leigh syndrome (LS); Friedreich ataxia (FRDA); mitochondrial superoxide dismutase (Mn-SOD); Cu,Zn-superoxide dismutase (Cu,Zn-SOD); β-amyloid peptide (Aβ); progressive supranuclear palsy (PSP); terminal deoxynucleotidyl transferase

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