2015/10/28 by Hyeonseung Yu, Peter Lee, Jaehyun Peter Lee +6
Engineering · Medicine · Physics and Astronomy · #Biology #Biomedical engineering #Ex vivo #In vivo #Materials science #Medical imaging #Medicine #Optical Coherence Tomography Applications #Optical coherence tomography #Optical tomography #Optics #Orbital Angular Momentum in Optics #Penetration depth #Physics #Preclinical imaging #Radiology #Random lasers and scattering media #Tomography #Wavefront #physics.med-ph #physics.optics
paper · pdf · doi:10.1117/1.jbo.21.10.101406
arxiv created 2015/10/28 · openalex publication_date 2016/02/19 · arxiv updated 2016/04/20 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/05
Multiple light scattering in tissue limits the penetration of optical coherence tomography (OCT) imaging. Here, we present in vivo OCT imaging of a live mouse using wavefront shaping (WS) to enhance the penetration depth. A digital micromirror device was used in a spectral-domain OCT system for complex WS of an incident beam which resulted in the optimal delivery of light energy into deep tissue. Ex vivo imaging of chicken breasts and mouse ear tissues showed enhancements in the strength of the image signals and the penetration depth, and in vivo imaging of the tail of a live mouse provided a multilayered structure inside the tissue.