Inflammatory links between obesity and metabolic disease

2011/06/01 by Carey N. Lumeng, Alan R. Saltiel · 32 citations
Medicine · Neuroscience · #Adipokines, Inflammation, and Metabolic Diseases #Adipose Tissue and Metabolism #Regulation of Appetite and Obesity

paper · pdf · doi:10.1172/jci57132

Abstract

The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity. This has led to a convergence of the fields of immunology and nutrient physiology and the understanding that they are inextricably linked. The reframing of obesity as an inflammatory condition has had a wide impact on our conceptualization of obesity-associated diseases. In this Review, we highlight the cellular and molecular mechanisms at play in the generation of obesity-induced inflammation. We also emphasize how defining the immune regulation in metabolic tissues has broadened the understanding of the diversity of inflammatory responses.

Citations

• Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
• Obesity is associated with macrophage accumulation in adipose tissue

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• Obesity is associated with hypothalamic injury in rodents and humans. [europepmc]
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• NLRP3 inflammasome in cancer and metabolic diseases. [europepmc]

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