Inflammatory links between obesity and metabolic disease

2011/06/01 by Carey N. Lumeng, Alan R. Saltiel · 2,284 citations
Medicine · Neuroscience · Psychology · #Adipokines, Inflammation, and Metabolic Diseases #Adipose Tissue and Metabolism #Bioinformatics #Biology #Cognitive reframing #Conceptualization #Disease #Immune system #Immunology #Inflammation #Internal medicine #Medicine #Obesity #Psychology #Regulation of Appetite and Obesity

paper · pdf · doi:10.1172/jci57132

published in Journal of Clinical Investigation 121(6), 2111-2117 (American Society for Clinical Investigation)

openalex publication_date 2011/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity. This has led to a convergence of the fields of immunology and nutrient physiology and the understanding that they are inextricably linked. The reframing of obesity as an inflammatory condition has had a wide impact on our conceptualization of obesity-associated diseases. In this Review, we highlight the cellular and molecular mechanisms at play in the generation of obesity-induced inflammation. We also emphasize how defining the immune regulation in metabolic tissues has broadened the understanding of the diversity of inflammatory responses.

Citations

• Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
• Obesity is associated with macrophage accumulation in adipose tissue

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• Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. [europepmc]
• Impact of the gut microbiota on inflammation, obesity, and metabolic disease. [europepmc]
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• Control of brown and beige fat development. [europepmc]
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• Inflammatory mechanisms linking obesity and metabolic disease. [europepmc]
• The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases. [europepmc]
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• Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. [europepmc]
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• NLRP3 inflammasome in cancer and metabolic diseases. [europepmc]

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