PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

2006/03/01 by Brian N. Finck, B. N. Finck · 35 citations
Medicine · Neuroscience · #Adipose Tissue and Metabolism #Nuclear Receptors and Signaling #Hormonal Regulation and Hypertension

paper · pdf · doi:10.1172/jci27794

Abstract

Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.

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