2010/06/08 by Douglas R. Lowy, Karl Münger · 1 citation
Medicine · Dentistry · #Head and Neck Cancer Studies #Cervical Cancer and HPV Research #Oral Health Pathology and Treatment
paper · doi:10.1056/nejme1003607
openalex publication_date 2010/06/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Identification of human papillomavirus (HPV) as the etiologic agent of cervical cancer has led to its identification in other cancers, with oropharyngeal squamous-cell carcinoma the most common of these.1,2 In this issue of the Journal, Ang and colleagues3 report findings from their study (ClinicalTrials.gov number, NCT00047008) that contribute to the growing body of evidence that HPV-positive oropharyngeal squamous-cell carcinoma represents a distinct clinicopathological entity associated with a better prognosis than HPV-negative oropharyngeal squamous-cell carcinoma.4,5 In a randomized trial of patients with oropharyngeal squamous-cell carcinoma, the overall survival was substantially better among patients with HPV-positive cancer than among patients . . .