2015/01/01 by Edward D. H. Mansfield, Katy Sillence, Patrick Hole +2 · 3 citations
Chemistry · Materials Science · Pharmacology, Toxicology and Pharmaceutics · #Advanced Drug Delivery Systems #Bioavailability #Biochemistry #Chemical engineering #Chemistry #Drug Solubulity and Delivery Systems #Drug delivery #Ethylene glycol #Materials science #Membrane #Nanomaterials #Nanomedicine #Nanoparticle #Nanoparticle-Based Drug Delivery #Nanotechnology #Organic chemistry #PEG ratio #Permeation #Pharmacology #Surface modification
paper · pdf · doi:10.1039/c5nr03178h
openalex publication_date 2015/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/02
The increasing use of nanoparticles in the pharmaceutical industry is generating concomitant interest in developing nanomaterials that can rapidly penetrate into, and permeate through, biological membranes to facilitate drug delivery and improve the bioavailability of active pharmaceutical ingredients. Here, we demonstrate that the permeation of thiolated silica nanoparticles through porcine gastric mucosa can be significantly enhanced by their functionalization with either 5 kDa poly(2-ethyl-2-oxazoline) or poly(ethylene glycol). Nanoparticle diffusion was assessed using two independent techniques; Nanoparticle Tracking Analysis, and fluorescence microscopy. Our results show that poly(2-ethyl-2-oxazoline) and poly(ethylene glycol) have comparable abilities to enhance diffusion of silica nanoparticles in mucin dispersions and through the gastric mucosa. These findings provide a new strategy in the design of nanomedicines, by surface modification or nanoparticle core construction, for enhanced transmucosal drug delivery.