2012/09/18 by Harvey F. Lodish · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #RNA and protein synthesis mechanisms #RNA modifications and cancer #Erythrocyte Function and Pathophysiology
paper · pdf · doi:10.1074/jbc.x112.420356
openalex publication_date 2012/09/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
For the past fifty-five years, much of my research has focused on the function and biogenesis of red blood cells, including the cloning and study of many membrane proteins such as glucose and anion transporters and the erythropoietin receptor. We have also elucidated the mechanisms of membrane insertion, folding, and maturation of many plasma membrane and secreted proteins. Despite all of this work and more, I remain extremely proud of our very early work on the regulation of mRNA translation: work on bacteriophage f2 RNA in the 1960s and on translation of α- and β-globin mRNAs in the early 1970s. Using techniques hopelessly antiquated by today's standards, we correctly elucidated many important aspects of translational control, and I thought readers would be interested in learning how we did these experiments.