2004/12/31 by Christian Kirchner, Tim Liedl, Stefan Kudera +6 · 2 citations
Materials Science · Engineering · #Quantum Dots Synthesis And Properties #Chalcogenide Semiconductor Thin Films #Gold and Silver Nanoparticles Synthesis and Applications
paper · doi:10.1021/nl047996m
openalex publication_date 2004/12/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Cytotoxicity of CdSe and CdSe/ZnS nanoparticles has been investigated for different surface modifications such as coating with mercaptopropionic acid, silanization, and polymer coating. For all cases, quantitative values for the onset of cytotoxic effects in serum-free culture media are given. These values are correlated with microscope images in which the uptake of the particles by the cells has been investigated. Our data suggest that in addition to the release of toxic Cd(2+) ions from the particles also their surface chemistry, in particular their stability toward aggregation, plays an important role for cytotoxic effects. Additional patch clamp experiments investigate effects of the particles on currents through ion channels.