Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

2011/01/16 by Hiroshi Nishimasu, Shinichi Okudaira, Kotaro Hama +7 · 2 citations
Biochemistry, Genetics and Molecular Biology · #Endoplasmic Reticulum Stress and Disease #Lipid Membrane Structure and Behavior #Sphingolipid Metabolism and Signaling

paper · doi:10.1038/nsmb.1998

crossref issued 2011/01/16 · crossref published 2011/01/16 · crossref published-online 2011/01/16 · openalex publication_date 2011/01/16 · crossref created 2011/01/16 · crossref published-print 2011/02/01 · crossref deposited 2023/05/19 · openalex created_date 2025/10/10 · crossref indexed 2026/07/23 · openalex updated_date 2026/07/25

Citations

• Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells
• Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase
• Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

Cited by

• Autotaxin in the crosshairs: Taking aim at cancer and other inflammatory conditions
• Autotaxin [wikipedia]