2007/08/16 by Eduardo M. Torres, Tanya Sokolsky, Cheryl M. Tucker +4 · 4 citations
Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · #Fungal and yeast genetics research #Plant Disease Resistance and Genetics #Plant nutrient uptake and metabolism
paper · doi:10.1126/science.1142210
openalex publication_date 2007/08/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Aneuploidy is a condition frequently found in tumor cells, but its effect on cellular physiology is not known. We have characterized one aspect of aneuploidy: the gain of extra chromosomes. We created a collection of haploid yeast strains that each bear an extra copy of one or more of almost all of the yeast chromosomes. Their characterization revealed that aneuploid strains share a number of phenotypes, including defects in cell cycle progression, increased glucose uptake, and increased sensitivity to conditions interfering with protein synthesis and protein folding. These phenotypes were observed only in strains carrying additional yeast genes, which indicates that they reflect the consequences of additional protein production as well as the resulting imbalances in cellular protein composition. We conclude that aneuploidy causes not only a proliferative disadvantage but also a set of phenotypes that is independent of the identity of the individual extra chromosomes.