2002/04/15 by Stephen L. Hoffman, Lucy M. L. Goh, Thomas Luke +14 · 5 citations
Medicine · Immunology and Microbiology · #Malaria Research and Control #Mosquito-borne diseases and control #Aquaculture disease management and microbiota
paper · pdf · doi:10.1086/339409
openalex publication_date 2002/04/15 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/22
During 1989-1999, 11 volunteers were immunized by the bites of 1001-2927 irradiated mosquitoes harboring infectious sporozoites of Plasmodium falciparum (Pf) strain NF54 or clone 3D7/NF54. Ten volunteers were first challenged by the bites of Pf-infected mosquitoes 2-9 weeks after the last immunization, and all were protected. A volunteer challenged 10 weeks after the last immunization was not protected. Five previously protected volunteers were rechallenged 23-42 weeks after a secondary immunization, and 4 were protected. Two volunteers were protected when rechallenged with a heterologous Pf strain (7G8). In total, there was protection in 24 of 26 challenges. These results expand published findings demonstrating that immunization by exposure to thousands of mosquitoes carrying radiation-attenuated Pf sporozoites is safe and well tolerated and elicits strain-transcendent protective immunity that persists for at least 42 weeks.