1998/11/06 by Malcolm J. Gardner, Hervé Tettelin, Daniel J. Carucci +24 · 2 citations
Medicine · Immunology and Microbiology · #Malaria Research and Control #Invertebrate Immune Response Mechanisms #Mosquito-borne diseases and control
paper · doi:10.1126/science.282.5391.1126
openalex publication_date 1998/11/06 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/31
Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.