2009/03/15 by Nadia Cattane, Roberta Rossi, Mariangela Lanfredi +2 · 2 citations
Medicine · Neuroscience · Psychology · #Bipolar Disorder and Treatment #Child and Adolescent Psychosocial and Emotional Development #Neuropeptides and Animal Physiology #Personality Disorders and Psychopathology #Stress Responses and Cortisol
paper · pdf · doi:10.1186/s12888-017-1383-2
openalex publication_date 2009/03/15 · openalex created_date 2016/06/24 · openalex updated_date 2026/06/23
We prove the role of alterations in Hypothalamic-Pituitary-Adrenal (HPA) axis, in neurotrasmission, in the endogenous opioid system and in neuroplasticity in the childhood trauma-associated vulnerability to develop BPD; we also confirm the presence of morphological changes in several BPD brain areas and in particular in those involved in stress response. Not so many studies are available on epigenetic changes in BPD patients, although these mechanisms are widely investigated in relation to stress-related disorders. A better comprehension of the biological and epigenetic mechanisms, affected by childhood trauma and altered in BPD patients, could allow to identify "at high risk" subjects and to prevent or minimize the development of the disease later in life.