Inflammation-associated lymphangiogenesis: a double-edged sword?
2014/03/03 by Honsoul Kim, Raghu P. Kataru, Gou Young Koh · 231 citations
Medicine · #Bioinformatics #Biology #Cancer #Cancer research #Immunology #Inflammation #Internal medicine #Lymphangiogenesis #Lymphatic System and Diseases #Lymphatic system #Medicine #Metastasis #Pathology #Pathophysiology #Sympathectomy and Hyperhidrosis Treatments #VEGF receptors #Vascular Malformations and Hemangiomas
paper · pdf · doi:10.1172/jci71607
published in Journal of Clinical Investigation 124(3), 936-942 (American Society for Clinical Investigation)
openalex publication_date 2014/03/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Abstract
Lymphangiogenesis and lymphatic vessel remodeling are complex biological processes frequently observed during inflammation. Accumulating evidence indicates that inflammation-associated lymphangiogenesis (IAL) is not merely an endpoint event, but actually a phenomenon actively involved in the pathophysiology of various inflammatory disorders. The VEGF-C/VEGFR-3 and VEGF-A/VEGF-R2 signaling pathways are two of the best-studied pathways in IAL. Methods targeting these molecules, such as prolymphangiogenic or antilymphatic treatments, were found to be beneficial in various preclinical and/or clinical studies. This Review focuses on the most recent achievements in the fields of lymphatic biology relevant to inflammatory conditions. Additionally, preclinical and clinical therapies that modulate IAL are summarized.
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