B cells expressing the transcription factor T-bet drive lupus-like autoimmunity
2017/02/26 by Kira Rubtsova, Anatoly V. Rubtsov, Joshua M. Thurman +3 · 33 citations
Immunology and Microbiology · Medicine · #T-cell and B-cell Immunology #Immune Cell Function and Interaction #Systemic Lupus Erythematosus Research
paper · pdf · doi:10.1172/jci91250
Abstract
B cells contribute to multiple aspects of autoimmune disorders and may play a role in triggering disease. Thus, targeting B cells may be a promising strategy for treating autoimmune disorders. Better understanding of the B cell subsets that are responsible for the development of autoimmunity will be critical for developing efficient therapies. Here we have reported that B cells expressing the transcription factor T-bet promote the rapid appearance of autoantibodies and germinal centers in spontaneous murine models of systemic lupus erythematosus (SLE). Conditional deletion of T-bet from B cells impaired the formation of germinal centers and mitigated the development of kidney damage and rapid mortality in SLE mice. B cell-specific deletion of T-bet was also associated with lower activation of both B cells and T cells. Taken together, our results suggest that targeting T-bet-expressing B cells may be a potential target for therapy for autoimmune diseases.
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