2019/12/12 by Nigare Raheem, Suzana K. Straus · 367 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · #Antibiotics #Antimicrobial #Antimicrobial Peptides and Activities #Antimicrobial peptides #Biochemical and Structural Characterization #Biochemistry #Biology #Chemical Synthesis and Analysis #Chemistry #Computational biology #Context (archaeology) #In vitro #Mechanism of action #Microbiology
paper · pdf · doi:10.3389/fmicb.2019.02866
published in Frontiers in Microbiology 10, 2866 (Frontiers Media)
openalex publication_date 2019/12/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
The antibiotic crisis has led to a pressing need for alternatives such as antimicrobial peptides (AMPs). Recent work has shown that these molecules have great potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, anti-cancer agents and anti-inflammatories. A better understanding of the mechanism of action (MOA) of AMPs is an important part of the discovery of more potent and less toxic AMPs. Many models and techniques have been utilized to describe the MOA. This review will examine how biological assays and biophysical methods can be utilized in the context of the specific antibacterial and antibiofilm functions of AMPs.