1957/07/06 by R. A. Fisher · 2 citations
Medicine · #Renal Diseases and Glomerulopathies #Bipolar Disorder and Treatment #Chronic Kidney Disease and Diabetes
paper · doi:10.1136/bmj.2.5035.43
openalex publication_date 1957/07/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Rates of many types of severe kidney disease are much higher in Black individuals than most other ethnic groups. Much of this disparity can now be attributed to genetic variants in the apoL1 (APOL1) gene found only in individuals with recent African ancestry. These variants greatly increase rates of hypertension-associated ESKD, FSGS, HIV-associated nephropathy, and other forms of nondiabetic kidney disease. We discuss the population genetics of APOL1 risk variants and the clinical spectrum of APOL1 nephropathy. We then consider clinical issues that arise for the practicing nephrologist caring for the patient who may have APOL1 kidney disease.