2020/02/20 by Márcio L. Rodrigues, Joshua D. Nosanchuk · 1 citation
Medicine · Veterinary · #Antifungal resistance and susceptibility #Fungal Infections and Studies #Infectious Diseases and Mycology
paper · pdf · doi:10.1371/journal.pntd.0007964
openalex publication_date 2020/02/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03
Human fungal diseases differ fundamentally from other infections in diverse ways. As eukaryotic pathogens, fungi share many similarities with their host cells, which impairs the development of antifungal compounds. Fungal tropism is highly variable, as pathogens infect a wide range of cell types. A single fungal pathogen can infect multiple tissues in the same patient (depending on the host's immunological status) and can undergo morphogenic shifts during infection. Fungi are still underappreciated as major pathogens by both the public and public health officials. Diseases caused by protozoa, bacteria, and viruses have been recognized as important public health issues for centuries. For instance, syphilis, influenza, and Chagas disease have been documented for over 100 years [1], while invasive mycoses were only widely acknowledged as medically important pathogens in the 1980s