2000/04/01 by Lorenz Poellinger · 4 citations
Chemistry · Environmental Science · #Effects and risks of endocrine disrupting chemicals #Mass Spectrometry Techniques and Applications #Toxic Organic Pollutants Impact
paper · doi:10.1080/026520300283333
crossref issued 2000/04/01 · crossref published 2000/04/01 · crossref published-print 2000/04/01 · openalex publication_date 2000/04/01 · crossref created 2002/07/26 · crossref deposited 2021/05/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29 · crossref indexed 2026/08/04
The Ah receptor mediates the toxicological responses of 2,3,7,8-TCDD and related compounds. Receptor-deficient animals were shown to be resistant to the toxic effects of dioxin, although there is also evidence for the existence of a receptor-independent pathway for dioxin-induced toxicity. In the cytosol the receptor is present in a non-activated ligand binding conformation. Association with Arnt in the nucleus turns the receptor complex into a ligand activated form. The physiological role of the receptor is not yet understood; however, the conservation of the receptor in a wide range of animal species (including humans) suggests a fundamental role in cellular physiology.