Childhood Obesity, Diabetes, and Cardiovascular Disease Risk
2023/06/16 by Mostafa Salama, Mostafa A. Salama, Babu Balagopal +2 · 25 citations
Medicine · #Obesity, Physical Activity, Diet #Birth, Development, and Health #Diet, Metabolism, and Disease
paper · pdf · doi:10.1210/clinem/dgad361
Abstract
This mini-review aims to briefly summarize the pathophysiology of childhood obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) risk in children and adolescents. Recent data on efficacy of lifestyle interventions, medications, and metabolic surgery for obesity, T2DM, and CVD risk factors are also reviewed. We conducted a PubMed search of English-language original and review articles relevant to childhood obesity, T2DM, and CVD risk factors, and biomarkers in children with an emphasis on recent publications. Childhood obesity arises from an intricate interaction between genetic, physiologic, environmental, and socioeconomic factors. The rise in the prevalence of childhood obesity is associated with the development of comorbidities including T2DM and CVD at an early age. A multipronged approach is central to the detection, monitoring, and management of childhood obesity and associated adverse metabolic consequences.
Citations
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- Prospecting the theragnostic potential of the psycho-neuro-endocrinological perturbation of the gut-brain-immune axis for improving cardiovascular diseases outcomes. [europepmc]
- The Ongoing Impact of COVID-19 on Pediatric Obesity. [europepmc]
- Creatine Acts as a Mediator of the Causal Effect of Obesity on Puberty Onset in Girls: Evidence from Mediation Mendelian Randomization Study. [europepmc]
- Association between late bedtime and obesity in children and adolescents: a meta-analysis. [europepmc]
- Circulating chemerin and interleukin-6 in children with obesity: possible metabolic risk predictors. [europepmc]
- Global, regional, and national burden of childhood cardiovascular disease: trends from 1990 to 2021. [europepmc]
- Associations of adolescent obesity with hypertension, diabetes mellitus and polycystic ovaries in Arabs and Jews in Israel-a nationwide study. [europepmc]
- Children's birth weight and the risk of general obesity and central obesity in primary school children: a 4-year longitudinal study. [europepmc]
- Association of Serum Uric Acid Levels with Cardiometabolic Factors in Adolescents with Obesity: A Cross-Sectional Study. [europepmc]
- Brain-Derived Neurotrophic Factor (BDNF) and Sex Differences in Metabolic Regulation. [europepmc]
- Role of Adipokines Chemerin, Visfatin, and Omentin in Obesity and Their Inflammatory and Metabolic Implications. [europepmc]
- Jumping hurdles: a grounded theory study of factors influencing school nurses' role in pediatric obesity prevention in Saudi Arabia. [europepmc]
- A study on the impact of childhood obesity on health-related physical fitness through motor coordination-related functional pathways. [europepmc]
- Prevalence of wasting, overweight and obesity among children under 5 years in 10 cities of Jiangsu Province: a multi-center cross-sectional study. [europepmc]
- Diagnostic Model for Obesity and Type 2 Diabetes Mellitus Based on Feature Selection from Fatty Acids, Amino Acids, and Clinical Characteristics. [europepmc]
- Feeding the hospitalized large-for-gestational-age infant: Clinical dilemmas and the need for growth standards. [europepmc]
- Environmental Determinants of Pediatric Obesity: An Epidemiological Review. [europepmc]
- Impact of Enhanced Family Education on BMI Changes in Children and Adolescents With Overweight or Obesity: Study Protocol for a City-Wide Cluster Randomized Controlled Trial. [europepmc]
- Depression comorbidity in children and adolescents with type 2 diabetes mellitus: a systematic review and meta-analysis. [europepmc]
- A Comprehensive Analysis of the Impact of Nutrient Intakes on the Stages and Mortality of Cardiovascular-Kidney-Metabolic Syndrome. [europepmc]
- Adipose-inflammatory factor profiles in children with metabolically healthy obesity and their correlation with NAFLD severity. [europepmc]
- Physical activity, social support and BMI among middle school students in China. [europepmc]
- Industrial Food Systems as Environmental Drivers of Women's Health and Childhood Obesity: A Cross-National Ecological Study. [europepmc]
- Association of birth weight with general obesity, central obesity, and MASLD in a nationally representative sample of US adolescents: A cross-sectional study from NHANES 1999 to 2020. [europepmc]
- Early maternal obesity shapes offspring development through immune mechanisms: a systematized review. [europepmc]
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