Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy

2010/08/20 by Angelo Guainazzi, Orlando D. Schärer · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer therapeutics and mechanisms #DNA Repair Mechanisms #PARP inhibition in cancer therapy

paper · doi:10.1007/s00018-010-0492-6

openalex publication_date 2010/08/20 · crossref created 2010/08/20 · crossref issued 2010/08/21 · crossref published 2010/08/21 · crossref published-online 2010/08/21 · crossref published-print 2010/11/01 · crossref deposited 2020/06/10 · openalex created_date 2025/10/10 · crossref indexed 2026/04/03 · openalex updated_date 2026/08/01

Citations

• The reaction of mono- and di-functional alkylating agents with nucleic acids
• Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
• Mechlorethamine cross-links deoxyguanosine residues at 5'-GNC sequences in duplex DNA fragments
• Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair
• Covalent structure of a nitrogen mustard-induced DNA interstrand cross-link: an N7-to-N7 linkage of deoxyguanosine residues at the duplex sequence 5'-d(GNC)
• The Biological Actions and Therapeutic Applications of the B-Chloroethyl Amines and Sulfides
• A History of Cancer Chemotherapy
• „REVERSIBLE” DNA

Cited by

• Nitrogen mustard [wikipedia]