2005/06/07 by Vinod Kumar · 2 citations
Medicine · #Poisoning and overdose treatments
paper · pdf · doi:10.1055/s-2005-869872
openalex publication_date 2005/06/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
All articles of this category Introduction Cyanamides are versatile synthons that can be transformed into many biologically active compounds such as ureas, thioureas, selenoureas, guanidines, hydroxyguanidines, creatine, and a large number of heterocyclic compounds. Cyanogen bromide is a very useful and extensively used reagent for the synthesis of cyanamides. It is a colorless or white crystalline solid that decomposes in the presence of moisture and has a very small liquid range (mp 50-53 °C, bp 61-62 °C). It is cheap and can be obtained commercially, or it can be synthesized by the reaction of sodium cyanide with bromine in aqueous medium. [ 1 ] Caution! It is highly toxic. Reactions should be carried out in a well-ventilated hood. CNBr produces electrophilic cyanide. Therefore, it is attacked by nucleophiles such as amines, alcohols and thiols. Organic chemists are fully utilizing this property of the reagent. CNBr has also been applied in molecular biology to digest some proteins, and as a coupling agent for phosphoramidate or pyrophosphate internucleotide bonds in DNA duplexes.