1965/09/01 by D. R. Fulkerson, Delbert Fulkerson, Oliver Gross · 31 citations
Biochemistry, Genetics and Molecular Biology · Computer Science · Mathematics · #Combinatorics #DNA and Biological Computing #Evolutionary Algorithms and Applications #Geometry #Incidence (geometry) #Incidence matrix #Interval (graph theory) #Mathematics
paper · pdf · doi:10.2140/pjm.1965.15.835
crossref issued 1965/09/01 · crossref published 1965/09/01 · crossref published-print 1965/09/01 · openalex publication_date 1965/09/01 · crossref created 2012/11/30 · crossref deposited 2017/03/11 · openalex created_date 2025/10/10 · crossref indexed 2026/07/31 · openalex updated_date 2026/08/01
Abstract : According to present genetic theory, the fine structure of genes consists of linearly ordered elements. A mutant gene is obtained by alteration of some connected portion of this structure. By examining data obtained from suitable experiments, it can be determined whether or not the blemished portions of two mutant genes intersect or not, and thus intersection data for a large number of mutants can be represented as an undirected graph. If this graph is an interval graph, then the observed data is consistent with a linear model of the gene. The problem of determining when a graph is an interval graph is a special case of the following problem concerning (0, 1)-matrices: When can the rows of such a matrix be permuted so as to make the 1's in each colum appear consecutively. A complete theory is obtained for this latter problem, culminating in a decomposition theorem which leads to a rapid algorithm for deciding the question, and for constructing the desired permutation when one exists.