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Number sequence representation of protein structures based on the second derivative of a folded tetrahedron sequence

2006/10/09 by Naoto Morikawa, Morikawa, Naoto
Biochemistry, Genetics and Molecular Biology · Materials Science · #Biomolecules (q-bio.BM) #Computational Geometry (cs.CG) #Discrete Mathematics (cs.DM) #Enzyme Structure and Function #FOS: Biological sciences #FOS: Computer and information sciences #FOS: Mathematics #Metric Geometry (math.MG) #Protein Structure and Dynamics #RNA and protein synthesis mechanisms

paper · pdf · doi:10.48550/arxiv.q-bio/0610017

openalex publication_date 2006/10/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

This paper proposes a new mathematical approach to characterize native protein structures based on the discrete differential geometry of tetrahedron tiles. In the approach, local structure of proteins is classified into finite types according to shape. And one would obtain a number sequence representation of protein structures automatically. As a result, it would become possible to quantify structural preference of amino-acids objectively. And one could use the wide variety of sequence alignment programs to study protein structures since the number sequence has no internal structure. The programs and this paper with clear figures are available from http://www.genocript.com.

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