2003/03/01 by Jieping Zhu · 1 citation
Chemistry · Biochemistry, Genetics and Molecular Biology · #Multicomponent Synthesis of Heterocycles #Chemical Synthesis and Analysis #Click Chemistry and Applications
paper · doi:10.1002/ejoc.200390167
openalex publication_date 2003/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
Abstract Although the synthesis of β‐lactams by means of tethered Ugi reactions has been known since the early 1960s, the 1995 report from Ugi’s group could be regarded as a turning point in the development of novel multicomponent reactions (MCRs) for heterocycle syntheses. Indeed, the number of articles describing isocyanide‐based multicomponent syntheses of heterocycles has increased steadily since then. Although most of these novel MCRs still exploit the archetypal reactivity of isocyanide, its pronounced ability to undergo α‐addition with electrophiles (sp 2 ‐ and sp‐carbon atoms) and nucleophiles, new MCRs have also been discovered as a consequence of exploiting the different secondary reactions of this α‐adduct. Since most of these MCRs were devised on the basis of known bimolecular reactions, judicious combination of reactive functional groups within substrates is of fundamental importance. While the combinatorial principle can help in finding and exploring new MCRs, we would advocate a “substrate‐design approach” in searching for novel MCRs. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)