Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA–topoisomerase I complex

2007/08/30 by Hue Thi My Van, Quynh Manh Le, Kwang Youl Lee +7 · 3 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Bioactive Compounds and Antitumor Agents #Cancer therapeutics and mechanisms #Synthesis and bioactivity of alkaloids

paper · doi:10.1016/j.bmcl.2007.08.062

openalex publication_date 2007/08/30 · crossref created 2007/08/30 · crossref issued 2007/11/01 · crossref published 2007/11/01 · crossref published-print 2007/11/01 · openalex created_date 2025/10/10 · crossref deposited 2025/10/18 · crossref indexed 2026/03/19 · openalex updated_date 2026/06/23

Citations

• Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex
• Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles
• Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors

Cited by

• The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
• Synthesis of Biologically Active Indenoisoquinoline Derivatives via a One-Pot Copper(II)-Catalyzed Tandem Reaction
• Topoisomerase inhibitor [wikipedia]