Selection of patients for radiotherapy with protons aiming at reduction of side effects: The model-based approach

2013/06/01 by Johannes A. Langendijk, Philippe Lambin, Dirk De Ruysscher +3 · 1 citation
Medicine · Physics and Astronomy · #Radiation Therapy and Dosimetry #Advanced Radiotherapy Techniques #Effects of Radiation Exposure

paper · pdf · doi:10.1016/j.radonc.2013.05.007

openalex publication_date 2013/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Abstract

Most new radiation techniques, have been introduced primarily to reduce the dose to normal tissues in order to prevent radiation-induced side effects. Radiotherapy with protons is such a radiation technique that due to its superior beam properties compared to photons enables better sparing of normal tissues. This paper describes a stepwise methodology to select patients for proton therapy when the primary aim is to reduce side effects. This method has been accepted by the Dutch health authorities to select patients for proton therapy. In addition, an alternative method is described in case randomised controlled trials are considered not appropriate.

Citations

• Adaptive radiotherapy for head and neck cancer—Dosimetric results from a prospective clinical trial

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