2000/05/01 by Ivar Mendez, Alain Dagher, Murray Hong +10 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · Social Sciences · #Global Education and Multiculturalism #Global Educational Policies and Reforms #Global Educational Reforms and Inequalities #Nerve injury and regeneration #Neurogenetic and Muscular Disorders Research #Pluripotent Stem Cells Research
paper · doi:10.3171/jns.2000.92.5.0863
openalex publication_date 2006/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluorodopa uptake from baseline values was observed 12 months postgrafting.