2014/09/11 by David P. Ryan, Theodore S. Hong, Nabeel Bardeesy · 2 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Pancreatic and Hepatic Oncology Research #Cancer Genomics and Diagnostics #Epigenetics and DNA Methylation
paper · doi:10.1056/nejmra1404198
openalex publication_date 2014/09/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Cancer of the pancreas is predominantly adenocarcinoma and involves activating KRAS mutations in the large majority of cases. Surgical resection can be effective in localized disease; combination chemotherapy offers some palliation in advanced disease.