2007/10/03 by Henry M. Feder, Barbara J. B. Johnson, Susan O’Çonnell +3 · 4 citations
Immunology and Microbiology · Medicine · Health Professions · #Vector-borne infectious diseases #Fibromyalgia and Chronic Fatigue Syndrome Research #Health, psychology, and well-being
paper · doi:10.1056/nejmra072023
openalex publication_date 2007/10/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
“Chronic Lyme disease” is often used to explain persistent pain, fatigue, and neurocognitive symptoms in patients without any evidence of previous acute Lyme disease. Once this diagnosis is given, prolonged treatment with multiple antimicrobial agents may follow. This review examines the scientific evidence for chronic borrelia infection and explains the approach to clinical evaluation and management in patients with a diagnosis of chronic Lyme disease.