1952/01/01 by J Férin · 1 citation
Biochemistry, Genetics and Molecular Biology · Environmental Science · #Estrogen and related hormone effects #Effects and risks of endocrine disrupting chemicals
paper · doi:10.1210/jcem-12-1-28
openalex publication_date 1952/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2025/11/06
THE duration of action of estrogens administered parenterally has been the subject of systematic research in test-animals, but no analogous systematic study of the duration of action of these substances has been undertaken in women. A certain degree of prolongation of the effect of estrogens was achieved early by esterification of the substances concerned (1–5), and more recently a further lengthening of the action has been achieved by employing improved microcrystalline suspensions (6) or emulsions (7). Only a few such preparations have been studied in women, and seldom have the effects of two or more preparations been compared in the same subjects. The studies on duration of action of estrogen which have been reported in the past have been based chiefly on the suppression of “hot flushes,” but the value of these data, based as it is upon a subjective response, has been disputed (8). In tests of this type, however, estradiol dipropionate proved to have more prolonged action than estrone (9) and estradiol-3-benzoate (10, 11). McGavack and associates (12, 13) have shown that a study of the “follicular reaction” of vaginal smears of women does not provide a ready means for determination of the duration of action of a standard dosage of estrogen.