The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies

2007/06/16 by Michelle A. Carey, Jeffrey W. Card, James W. Voltz +3 · 1 citation
Medicine · Agricultural and Biological Sciences · #Asthma and respiratory diseases #Neonatal Respiratory Health Research #Pharmacological Effects and Assays

paper · doi:10.1152/ajplung.00174.2007

openalex publication_date 2007/06/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Numerous animal studies have revealed significant effects of sex and sex hormones on normal lung development, lung physiology, and various lung diseases. The primary goal of this review is to summarize knowledge to date on the effects of sex and sex hormones on lung development, physiology, and disease in animals. Specific emphasis will be placed on fibrosis, allergic airway disease, acute lung injury models, respiratory infection, and lung toxicology studies.

Citations

• Sex hormones as immunomodulators in health and disease
• Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse
• Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones
• Estrogen regulates pulmonary alveolar formation, loss, and regeneration in mice

Cited by

• Estrogen receptor beta [wikipedia]