2015/04/21 by Tony M. Plant · 2 citations
Medicine · Psychology · #Hypothalamic control of reproductive hormones #Neuroendocrine regulation and behavior #Ovarian function and disorders
paper · pdf · doi:10.1530/joe-15-0113
openalex publication_date 2015/04/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
This review provides an outline of how our understanding of the neuroendocrine control of the hypothalamo-pituitary-gonadal axis has evolved since the publication of Geoffrey Harris' renowned monograph in 1955. Particular attention is directed to the neurobiology underlying pulsatile GnRH release from the hypothalamus, the neuroendocrine control of ovarian cycles, puberty and seasonality of gonadal function, and to ideas that have emerged as a result of examining the relationship between growth and the reproductive axis. The review closes with i) a brief discussion of how knowledge gained as a result of pursuing the early hypotheses of Harris has led to major clinical and therapeutic applications, and ii) a personal glimpse into the future of research in this fascinating area of biology.