2002/01/01 by Dong-Ju Jung, Soon-Young Na, Doe Sun Na +1 · 2 citations
Biochemistry, Genetics and Molecular Biology · #Retinoids in leukemia and cellular processes #Estrogen and related hormone effects #Chromatin Remodeling and Cancer
paper · pdf · doi:10.1074/jbc.m110417200
openalex publication_date 2002/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
Transcriptional coactivators either bridge transcription factors and the components of the basal transcription apparatus and/or remodel the chromatin structures. We isolated a novel nuclear protein based on its interaction with the recently described general coactivator activating signal cointegrator-2 (ASC-2). This protein CAPER (for coactivator of activating protein-1 (AP-1) and estrogen receptors (ERs)) selectively bound, among the many transcription factors we tested, the AP-1 component c-Jun and the estradiol-bound ligand binding domains of ERalpha and ERbeta. Interestingly, CAPER exhibited a cryptic autonomous transactivation function that becomes activated only in the presence of estradiol-bound ER. In cotransfections, CAPER stimulated transactivation by ERalpha, ERbeta, and AP-1. Thus, CAPER may represent a more selective transcriptional coactivator molecule that plays a pivotal role for the function of AP-1 and ERs in vivo in conjunction with the general coactivator ASC-2.