Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994/06/03 by Shlomit Halachmi, Emily Marden, Glover Martin +3 · 8 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Estrogen and related hormone effects #Inflammatory mediators and NSAID effects #Glutathione Transferases and Polymorphisms

paper · doi:10.1126/science.8197458

openalex publication_date 1994/06/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23

Abstract

The estrogen receptor is a transcription factor which, when bound to estradiol, binds DNA and regulates expression of estrogen-responsive genes. A 160-kilodalton estrogen receptor-associated protein, ERAP160, was identified that exhibits estradiol-dependent binding to the receptor. Mutational analysis of the receptor shows that its ability to activate transcription parallels its ability to bind ERAP160. Antiestrogens are unable to promote ERAP160 binding and can block the estrogen-dependent interaction of the receptor and ERAP160 in a dose-dependent manner. This evidence suggests that ERAP160 may mediate estradiol-dependent transcriptional activation by the estrogen receptor. Furthermore, the ability of antiestrogens to block estrogen receptor-ERAP160 complex formation could account for their therapeutic effects in breast cancer.

Citations

• The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

Cited by

• Analysis of the Steroid Receptor Coactivator 1 (SRC1)-CREB Binding Protein Interaction Interface and Its Importance for the Function of SRC1
• Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.
• BRG-1 Is Recruited to Estrogen-Responsive Promoters and Cooperates with Factors Involved in Histone Acetylation
• RIP-140 Interacts with Multiple Nuclear Receptors by Means of Two Distinct Sites
• POU Transcription Factors Brn-3a and Brn-3b Interact with the Estrogen Receptor and Differentially Regulate Transcriptional Activity via an Estrogen Response Element
• Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ
• Activating Signal Cointegrator 1, a Novel Transcription Coactivator of Nuclear Receptors, and Its Cytosolic Localization under Conditions of Serum Deprivation
• Estrogen receptor beta [wikipedia]