1946/06/01 by Simon Freed · 1 citation
Medicine · #Food Allergy and Anaphylaxis Research #Contact Dermatitis and Allergies #Biomedical and Chemical Research
paper · doi:10.1210/jcem-6-6-420
openalex publication_date 1946/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2025/11/06
ALARGE proportion of the preparations of sex hormones, both male and female, which are intended to be administered parenterally are dissolved in vegetable oil. While therapy with these preparations is both practical and satisfactory, there is a disadvantage to their administration in the fact that due to the oil vehicle there is a significant incidence of allergic or irritating action at the site of injection. These local reactions are not infrequent, and depend upon the type of vegetable oil used as a vehicle. The oils customarily used are derived from sesame, peanut or corn, and the incidence of reactions due to some of these oils may amount to 20 per cent. Sesame oil seems to be the least allergenic. Induration, itching, bleb formation and swelling of the neighboring tissues may be slight after the first or second injection, but they may become increasingly severe and may cause significant disability and pain for relatively long periods of time.