1944/05/06 by C. F. Fluhmann · 3 citations
Biochemistry, Genetics and Molecular Biology · Environmental Science · #Estrogen and related hormone effects #Effects and risks of endocrine disrupting chemicals #Steroid Chemistry and Biochemistry
paper · doi:10.1001/jama.1944.02850190003001
openalex publication_date 1944/05/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
The original concept of the ovary as an endocrine gland which may produce various clinical syndromes due to increased or decreased formation of some basic secretion was a very simple explanation of abnormal function. However, the advances of the past few years have shown that the problem is much more complicated, since many active biologic substances are concerned. They may be considered as falling into two main groups. First are the estrogens, or estrogenic substances, and second progestin or corpus luteum derivatives. <h3>A. ESTROGENIC SUBSTANCES</h3> The estrogens are chiefly concerned with the maintenance of the female accessory genital organs. Their production is not limited to the gonads, and various forms are found widely distributed in nature. They occur in both males and females and it is possible that some of these substances are produced by the adrenal glands. Under physiologic and experimental conditions they promote growth of the endometrium, the