1991/02/01 by Marie Keaveney, Jörg Klug, M. Dawson +4 · 3 citations
Biochemistry, Genetics and Molecular Biology · #Estrogen and related hormone effects
paper · doi:10.1677/jme.0.0060111
openalex publication_date 1991/02/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/09
The presence of a previously unidentified exon upstream of the originally described human oestrogen receptor (hOR) gene is demonstrated. This is shown to be spliced to the 5' untranslated region of the previously designated exon I. The resulting genomic structure of the human gene is thus in agreement with the structure of the mouse OR gene and highlights the conservation of an 18 amino acid upstream open-reading frame formed from the above splicing event. Taken in conjunction with previous publications this would suggest that the hOR gene is a complex transcriptional unit that contains two promoters.