1996/01/01 by Christopher O. Miles, A. ERASMUSON, Alistair L. Wilkins +5 · 2 citations
Agricultural and Biological Sciences · #Mycotoxins in Agriculture and Food
paper · doi:10.1021/jf9601325
openalex publication_date 1996/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/17
This is the first report of a metabolic conversion in animals of zearalenone to zearalanols. Zearalenone was labeled with deuterium by base-catalyzed isotope exchange. The labeled zearalenone, in the form of its β-cyclodextrin inclusion complex, was administered orally and intravenously to sheep. In addition to deuteriozearalenone glucuronide, analysis of the urine revealed the presence of deuteriated α- and β-zearalenol and α- and β-zearalanol glucuronides. No zearalanone was detected in the urine. The problem of cis−trans isomerization of zearalenone in the presence of sunlight is also discussed. Keywords: Zeranol; zearalanol; zearalenone; zearalenol; metabolism; residue; Fusarium; mycotoxin