2011/01/01 by Chao Zhang, Dongming Zhou, Manfred Grauer +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Business, Management and Accounting · Computer Science · Medicine · #Advanced Database Systems and Queries #Big Data and Business Intelligence #Business Process Modeling and Analysis #CAR-T cell therapy research #Viral gastroenteritis research and epidemiology #Virus-based gene therapy research
paper · pdf · doi:10.1080/21645515.2016.1165908
openalex publication_date 2011/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
Adenoviral vectors are widely employed against infectious diseases or cancers, as they can elicit specific antibody responses and T cell responses when they are armed with foreign genes as vaccine carriers, and induce apoptosis of the cancer cells when they are genetically modified for cancer therapy. In this review, we summarize the biological characteristics of adenovirus (Ad) and the latest development of Ad vector-based strategies for the prevention and control of emerging infectious diseases or cancers. Strategies to circumvent the pre-existing neutralizing antibodies which dampen the immunogenicity of Ad-based vaccines are also discussed.