2001/08/31 by Ivan Tkáč, Peter E. Andersen, Gregor Adriany +3 · 3 citations
Medicine · Chemistry · Physics and Astronomy · #Advanced MRI Techniques and Applications #Advanced NMR Techniques and Applications #NMR spectroscopy and applications
paper · pdf · doi:10.1002/mrm.1213
openalex publication_date 2001/08/31 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
In vivo 1H NMR spectra from the human brain were measured at 7 T. Ultrashort echo-time STEAM was used to minimize J-modulation and signal attenuation caused by the shorter T2 of metabolites. Precise adjustment of higher-order shims, which was achieved with FASTMAP, was crucial to benefit from this high magnetic field. Sensitivity improvements were evident from single-shot spectra and from the direct detection of glucose at 5.23 ppm in 8-ml volumes. The linewidth of the creatine methyl resonance was at best 9 Hz. In spite of the increased linewidth of singlet resonances at 7 T, the ability to resolve overlapping multiplets of J-coupled spin systems, such as glutamine and glutamate, was substantially increased. Characteristic spectral patterns of metabolites, e.g., myo-inositol and taurine, were discernible in the in vivo spectra, which facilitated an unambiguous signal assignment.