2014/04/01 by Laurent David, José M. Polo · 1 citation
Biochemistry, Genetics and Molecular Biology · #Pluripotent Stem Cells Research #CRISPR and Genetic Engineering #Renal and related cancers
paper · pdf · doi:10.1016/j.scr.2014.03.007
openalex publication_date 2014/04/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/02
Despite advances in the field of somatic cell reprogramming, an understanding and exploration of the underlying mechanisms governing this process are only recently emerging. It is now increasingly apparent that key sequential events correlate with the reprogramming process; a process previously thought to be random and unpredictable is now looking, to a greater extent, defined and controlled. Herein, we will review the key cellular and molecular events associated with the reprogramming process, giving an integrative and conciliatory view of the different studies addressing the mechanism of nuclear reprogramming.