Research Review: Environmental exposures, neurodevelopment, and child mental health – new paradigms for the study of brain and behavioral effects
2016/03/14 by Virginia Rauh, Virginia A. Rauh, Amy E. Margolis +1 · 26 citations
Environmental Science · Medicine · #Heavy Metal Exposure and Toxicity #Health, Environment, Cognitive Aging #Attention Deficit Hyperactivity Disorder
paper · doi:10.1111/jcpp.12537
Abstract
BACKGROUND: Environmental exposures play a critical role in the genesis of some child mental health problems. METHODS: We open with a discussion of children's vulnerability to neurotoxic substances, changes in the distribution of toxic exposures, and cooccurrence of social and physical exposures. We address trends in prevalence of mental health disorders, and approaches to the definition of disorders that are sensitive to the subtle effects of toxic exposures. We suggest broadening outcomes to include dimensional measures of autism spectrum disorders, attention-deficit hyperactivity disorder, and child learning capacity, as well as direct assessment of brain function. FINDINGS: We consider the impact of two important exposures on children's mental health: lead and pesticides. We argue that longitudinal research designs may capture the cascading effects of exposures across biological systems and the full-range of neuropsychological endpoints. Neuroimaging is a valuable tool for observing brain maturation under varying environmental conditions. A dimensional approach to measurement may be sensitive to subtle subclinical toxic effects, permitting the development of exposure-related profiles and testing of complex functional relationships between brain and behavior. Questions about the neurotoxic effects of chemicals become more pressing when viewed through the lens of environmental justice. CONCLUSIONS: Reduction in the burden of child mental health disorders will require longitudinal study of neurotoxic exposures, incorporating dimensional approaches to outcome assessment, and measures of brain function. Research that seeks to identify links between toxic exposures and mental health outcomes has enormous public health and societal value.
Citations
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- Pupil Size Tracks Attentional Performance In Attention-Deficit/Hyperactivity Disorder. [europepmc]
- Measurement framework for the Environmental influences on Child Health Outcomes research program. [europepmc]
- Environmental Mechanisms of Neurodevelopmental Toxicity. [europepmc]
- Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data. [europepmc]
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- Developmental Dieldrin Exposure Alters DNA Methylation at Genes Related to Dopaminergic Neuron Development and Parkinson's Disease in Mouse Midbrain. [europepmc]
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- Prenatal and Infancy Nurse Home Visiting and 18-Year Outcomes of a Randomized Trial. [europepmc]
- Early environmental risk factors for neurodevelopmental disorders - a systematic review of twin and sibling studies. [europepmc]
- Prenatal exposure to organophosphate pesticides and brain morphology and white matter microstructure in preadolescents. [europepmc]
- Environmental influence on neurodevelopmental disorders: Potential association of heavy metal exposure and autism. [europepmc]
- Prenatal PM 2.5 exposure and behavioral development in children from Mexico City. [europepmc]
- Environmental exposures and sleep outcomes: A review of evidence, potential mechanisms, and implications. [europepmc]
- Understanding the Link Between Allergy and Neurodevelopmental Disorders: A Current Review of Factors and Mechanisms. [europepmc]
- Autism Spectrum and Other Neurodevelopmental Disorders in Children of Immigrants: A Brief Review of Current Evidence and Implications for Clinical Practice. [europepmc]
- Neurobehavioral, Neuromotor, and Neurocognitive Effects in Agricultural Workers and Their Children Exposed to Pyrethroid Pesticides: A Review. [europepmc]
- Risk of lead exposure, subcortical brain structure, and cognition in a large cohort of 9- to 10-year-old children. [europepmc]
- The Interplay of Environmental Exposures and Mental Health: Setting an Agenda. [europepmc]
- Neurotoxicants, the Developing Brain, and Mental Health. [europepmc]
- Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review. [europepmc]
- Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities. [europepmc]
- The Minderoo-Monaco Commission on Plastics and Human Health. [europepmc]
- Disparities in Toxic Chemical Exposures and Associated Neurodevelopmental Outcomes: A Scoping Review and Systematic Evidence Map of the Epidemiological Literature. [europepmc]
- Machine learning-based health environmental-clinical risk scores in European children. [europepmc]
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