2008/09/16 by Matthew W. Powner, John D. Sutherland · 1 citation
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #RNA and protein synthesis mechanisms #DNA and Nucleic Acid Chemistry #Origins and Evolution of Life
paper · doi:10.1002/cbic.200800391
openalex publication_date 2008/09/16 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/02
Prebiotic nucleotide synthesis: two for the price of one! Photoanomerization of α-D-cytidine is extremely low yielding, but irradiation of the 2′-phosphate results in efficient anomerization and nucleobase hydrolysis such that both pyrimidine nucleotides needed for prebiotic RNA synthesis are produced in a single reaction.