1997/12/01 by A. N. Fedorov, Thomas Baldwin · 1 citation
Biochemistry, Genetics and Molecular Biology · #Ubiquitin and proteasome pathways #Protein Structure and Dynamics #Transgenic Plants and Applications
paper · pdf · doi:10.1074/jbc.272.52.32715
openalex publication_date 1997/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The problem of how the linear amino acid sequence of a polypeptide folds to assume its unique tertiary structure is one of the most basic and challenging conundrums of contemporary science. Many of the principles and characteristics of protein folding have been learned by studying refolding of denatured polypeptides. However, the problem of protein folding cannot be completely understood without reference to the biological context of protein folding, especially for large, multidomain, and multisubunit proteins.