1998/01/01 by Thierry Lagrange, Achillefs N. Kapanidis, Hong Tang +2 · 3 citations
Biochemistry, Genetics and Molecular Biology · #Genomics and Chromatin Dynamics #RNA Research and Splicing #RNA and protein synthesis mechanisms
paper · pdf · doi:10.1101/gad.12.1.34
openalex publication_date 1998/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
A sequence element located immediately upstream of the TATA element, and having the consensus sequence 5'-G/C-G/C-G/A-C-G-C-C-3', affects the ability of transcription factor IIB to enter transcription complexes and support transcription initiation. The sequence element is recognized directly by the transcription factor IIB. Recognition involves alpha-helices 4' and 5' of IIB, which comprise a helix-turn-helix DNA-binding motif. These observations establish that transcription initiation involves a fourth core promoter element, the IIB recognition element (BRE), in addition to the TATA element, the initiator element, and the downstream promoter element, and involves a second sequence-specific general transcription factor, IIB, in addition to transcription factor IID.