1999/01/01 by Lindsay M. Reynolds, Susan Cochran, Brian Morris +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · Health Professions · Neuroscience · Psychology · #Health and Lifestyle Studies #Neuroscience and Neuropharmacology Research #Neurotransmitter Receptor Influence on Behavior #Psychological Treatments and Disorders #Psychology Research and Bibliometrics #Receptor Mechanisms and Signaling
paper · doi:10.1016/j.schres.2004.02.003
openalex publication_date 1999/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/04/28
Administration of phencyclidine (PCP) to both humans and animals models the symptoms of schizophrenia. Brain concentrations of N-acetylaspartate (NAA) are reduced in this disease, reflecting neuronal dysfunction. This study investigates the effects in rats of a chronic intermittent regime of PCP on NAA and its precursor N-acetylaspartylglutamate (NAAG) in rat frontal and temporal cortex, hippocampus and striatum, determined by HPLC. We found significant PCP-induced deficits of NAA and NAAG only in the temporal cortex; NAAG was significantly elevated in the hippocampus. These changes closely reflect postmortem findings reported in schizophrenia.