Closed test procedures for the comparison of dose groups against a negative control group or placebo

2020/12/30 by Ludwig A. Hothorn, Hothorn, Ludwig A.
Biochemistry, Genetics and Molecular Biology · Mathematics · Pharmacology, Toxicology and Pharmaceutics · #Applications (stat.AP) #Carcinogens and Genotoxicity Assessment #FOS: Computer and information sciences #Pharmacogenetics and Drug Metabolism #Statistical Methods in Clinical Trials

paper · pdf · doi:10.48550/arxiv.2012.15093

openalex publication_date 2020/12/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Dose groups are compared with a control assuming an order restriction usually by the Williams trend test. Here, as an alternative, two variants of the closed testing procedure are considered, one where global Williams tests are used in the partition hypotheses, and another where pairwise contrast tests are used for this purpose. Related R software is provided.

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